Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness.
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ABSTRACT:
SUBMITTER: Hammerling MJ
PROVIDER: S-EPMC3932624 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness.
Hammerling Michael J MJ Ellefson Jared W JW Boutz Daniel R DR Marcotte Edward M EM Ellington Andrew D AD Barrick Jeffrey E JE
Nature chemical biology 20140202 3
Bioengineering advances have made it possible to fundamentally alter the genetic codes of organisms. However, the evolutionary consequences of expanding an organism's genetic code with a noncanonical amino acid are poorly understood. Here we show that bacteriophages evolved on a host that incorporates 3-iodotyrosine at the amber stop codon acquire neutral and beneficial mutations to this new amino acid in their proteins, demonstrating that an expanded genetic code increases evolvability. ...[more]
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