Ontology highlight
ABSTRACT:
SUBMITTER: Lee KE
PROVIDER: S-EPMC3932859 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Lee Kyung Eun KE Seo Jihae J Shin Jiheon J Ji Eun Hye EH Roh Jiwon J Kim Joo Yeon JY Sun Woong W Muhr Jonas J Lee Sanghyuk S Kim Jaesang J
Proceedings of the National Academy of Sciences of the United States of America 20140205 7
How a pool of undifferentiated neural progenitor cells is maintained in the developing nervous system is an issue that remains unresolved. One of the key transcription factors for self-renewal of these cells is Sox2, the forced expression of which has been shown to inhibit neuronal differentiation in vivo. To dissect the molecular mechanisms of Sox2 activity, a ChIP-on-chip assay has been carried out for Sox2, and multiple candidate direct target genes have been isolated. In this report, we prov ...[more]