Ontology highlight
ABSTRACT:
SUBMITTER: Maine CJ
PROVIDER: S-EPMC3933017 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Maine Christian J CJ Marquardt Kristi K Cheung Jocelyn J Sherman Linda A LA
Journal of immunology (Baltimore, Md. : 1950) 20140122 4
A single nucleotide polymorphism in PTPN22 (R620W), which encodes the Lyp tyrosine phosphatase, has been linked to a number of autoimmune diseases including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Studies in PTPN22 knockout (KO) mice and in mice expressing the mouse homolog of the pro-autoimmune allele, PEP(R619W), have reported increased germinal center activity and enhanced Ab production. In this article, we present findings that explain the basis for increased ...[more]