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Role of tissue protection in lethal respiratory viral-bacterial coinfection.

ABSTRACT: Secondary bacterial pneumonia leads to increased morbidity and mortality from influenza virus infections. What causes this increased susceptibility, however, is not well defined. Host defense from infection relies not only on immune resistance mechanisms but also on the ability to tolerate a given level of pathogen burden. Failure of either resistance or tolerance can contribute to disease severity, making it hard to distinguish their relative contribution. We employ a coinfection mouse model of influenza virus and Legionella pneumophila in which we can separate resistance and tolerance. We demonstrate that influenza virus can promote susceptibility to lethal bacterial coinfection, even when bacterial infection is controlled by the immune system. We propose that this failure of host defense is due to impaired ability to tolerate tissue damage.

SUBMITTER: Jamieson AM

PROVIDER: S-EPMC3933032 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Role of tissue protection in lethal respiratory viral-bacterial coinfection.

Jamieson Amanda M AM Pasman Lesley L Yu Shuang S Gamradt Pia P Homer Robert J RJ Decker Thomas T Medzhitov Ruslan R

Science (New York, N.Y.) 20130425 6137

Secondary bacterial pneumonia leads to increased morbidity and mortality from influenza virus infections. What causes this increased susceptibility, however, is not well defined. Host defense from infection relies not only on immune resistance mechanisms but also on the ability to tolerate a given level of pathogen burden. Failure of either resistance or tolerance can contribute to disease severity, making it hard to distinguish their relative contribution. We employ a coinfection mouse model of ...[more]

PMID: 23618765

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