Ontology highlight
ABSTRACT:
SUBMITTER: Petronijevic FR
PROVIDER: S-EPMC3934322 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20131122 49
The direct β-coupling of cyclic ketones with aryl ketones has been achieved via the synergistic combination of photoredox catalysis and organocatalysis. Diaryl oxymethyl or aryl-alkyl oxymethyl radicals, transiently generated via single-electron reduction of ketone precursors, readily merge with β-enaminyl radical species, generated by photon-induced enamine oxidation, to produce γ-hydroxyketone adducts. Experimental evidence indicates that two discrete reaction pathways can be operable in this ...[more]