Ontology highlight
ABSTRACT:
SUBMITTER: Takeo M
PROVIDER: S-EPMC3936678 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Takeo Makoto M Chou Wei Chin WC Sun Qi Q Lee Wendy W Rabbani Piul P Loomis Cynthia C Taketo M Mark MM Ito Mayumi M
Nature 20130612 7457
The tips of mammalian digits can regenerate after amputation, like those of amphibians. It is unknown why this capacity is limited to the area associated with the nail. Here we show that nail stem cells (NSCs) reside in the proximal nail matrix and that the mechanisms governing NSC differentiation are coupled directly with their ability to orchestrate digit regeneration. Early nail progenitors undergo Wnt-dependent differentiation into the nail. After amputation, this Wnt activation is required ...[more]