Ontology highlight
ABSTRACT:
SUBMITTER: Lee TH
PROVIDER: S-EPMC3937085 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Lee Ting-Hein TH McKleroy William W Khalifeh-Soltani Amin A Sakuma Stephen S Lazarev Stanislav S Riento Kirsi K Nishimura Stephen L SL Nichols Ben J BJ Atabai Kamran K
Molecular biology of the cell 20140108 5
Tissue fibrosis occurs when matrix production outpaces matrix degradation. Degradation of collagen, the main component of fibrotic tissue, is mediated through an extracellular proteolytic pathway and intracellular pathway of cellular uptake and lysosomal digestion. Recent studies demonstrate that disruption of the intracellular pathways can exacerbate fibrosis. These pathways are poorly characterized. Here we identify novel mediators of the intracellular pathway of collagen turnover through a ge ...[more]