Ontology highlight
ABSTRACT:
SUBMITTER: Welsbie DS
PROVIDER: S-EPMC5553555 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Welsbie Derek S DS Mitchell Katherine L KL Jaskula-Ranga Vinod V Sluch Valentin M VM Yang Zhiyong Z Kim Jessica J Buehler Eugen E Patel Amit A Martin Scott E SE Zhang Ping-Wu PW Ge Yan Y Duan Yukan Y Fuller John J Kim Byung-Jin BJ Hamed Eman E Chamling Xitiz X Lei Lei L Fraser Iain D C IDC Ronai Ze'ev A ZA Berlinicke Cynthia A CA Zack Donald J DJ
Neuron 20170601 6
Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To better understand the pathway through which DLK acts, we developed enhanced functional genomic screens in primary RGCs, including use of arrayed, whole-genome, small interfering RNA libraries. Explaining why DLK inhibition is only partially protective, we identify leucine zipper kinase (LZK) as cooperating with DLK to activate downstream s ...[more]