Ontology highlight
ABSTRACT:
SUBMITTER: Fan X
PROVIDER: S-EPMC3937121 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Fan Xuelai X Jin Wu Yang WY Lu Jie J Wang Jin J Wang Yu Tian YT
Nature neuroscience 20140126 3
Rapid and reversible methods for altering the levels of endogenous proteins are critically important for studying biological systems and developing therapeutics. Here we describe a membrane-permeant targeting peptide-based method that rapidly and reversibly knocks down endogenous proteins through chaperone-mediated autophagy in vitro and in vivo. We demonstrate the specificity, efficacy and generalizability of the method by showing efficient knockdown of various proteins, including death associa ...[more]