Ontology highlight
ABSTRACT:
SUBMITTER: Molnar I
PROVIDER: S-EPMC3937221 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Molnár Imre I Migh Ede E Szikora Szilárd S Kalmár Tibor T Végh Attila G AG Deák Ferenc F Barkó Szilvia S Bugyi Beáta B Orfanos Zacharias Z Kovács János J Juhász Gábor G Váró György G Nyitrai Miklós M Sparrow John J Mihály József J
PLoS genetics 20140227 2
During muscle development, myosin and actin containing filaments assemble into the highly organized sarcomeric structure critical for muscle function. Although sarcomerogenesis clearly involves the de novo formation of actin filaments, this process remained poorly understood. Here we show that mouse and Drosophila members of the DAAM formin family are sarcomere-associated actin assembly factors enriched at the Z-disc and M-band. Analysis of dDAAM mutants revealed a pivotal role in myofibrillogen ...[more]