Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth.
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ABSTRACT:
SUBMITTER: Balakrishnan M
PROVIDER: S-EPMC7479987 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth.
Balakrishnan Mridula M Yu Shannon F SF Chin Samantha M SM Soffar David B DB Windner Stefanie E SE Goode Bruce L BL Baylies Mary K MK
Cell reports 20200701 3
Sarcomeres, the fundamental contractile units of muscles, are conserved structures composed of actin thin filaments and myosin thick filaments. How sarcomeres are formed and maintained is not well understood. Here, we show that knockdown of Drosophila cofilin (DmCFL), an actin depolymerizing factor, disrupts both sarcomere structure and muscle function. The loss of DmCFL also results in the formation of sarcomeric protein aggregates and impairs sarcomere addition during growth. The activation of ...[more]
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