Ontology highlight
ABSTRACT:
SUBMITTER: Veesler D
PROVIDER: S-EPMC3939775 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Veesler David D Khayat Reza R Krishnamurthy Srinath S Snijder Joost J Huang Rick K RK Heck Albert J R AJ Anand Ganesh S GS Johnson John E JE
Structure (London, England : 1993) 20131219 2
Most double-stranded DNA (dsDNA) viruses, including bacteriophages and herpesviruses, rely on a staged assembly process of capsid formation. A viral protease is required for many of them to disconnect scaffolding domains/proteins from the capsid shell, therefore priming the maturation process. We used the bacteriophage HK97 as a model system to decipher the molecular mechanisms underlying the recruitment of the maturation protease by the assembling procapsid and the influence exerted onto the la ...[more]