Ontology highlight
ABSTRACT:
SUBMITTER: Ning J
PROVIDER: S-EPMC5159922 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ning Jiying J Erdemci-Tandogan Gonca G Yufenyuy Ernest L EL Wagner Jef J Himes Benjamin A BA Zhao Gongpu G Aiken Christopher C Zandi Roya R Zhang Peijun P
Nature communications 20161213
HIV-1 virions assemble as immature particles containing Gag polyproteins that are processed by the viral protease into individual components, resulting in the formation of mature infectious particles. There are two competing models for the process of forming the mature HIV-1 core: the disassembly and de novo reassembly model and the non-diffusional displacive model. To study the maturation pathway, we simulate HIV-1 maturation in vitro by digesting immature particles and assembled virus-like par ...[more]