Ontology highlight
ABSTRACT:
SUBMITTER: Parkinson Study Group SURE-PD Investigators
PROVIDER: S-EPMC3940333 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Schwarzschild Michael A MA Ascherio Alberto A Beal M Flint MF Cudkowicz Merit E ME Curhan Gary C GC Hare Joshua M JM Hooper D Craig DC Kieburtz Karl D KD Macklin Eric A EA Oakes David D Rudolph Alice A Shoulson Ira I Tennis Marsha K MK Espay Alberto J AJ Gartner Maureen M Hung Albert A Bwala Grace G Lenehan Richard R Encarnacion Elmyra E Ainslie Melissa M Castillo Richard R Togasaki Daniel D Barles Gina G Friedman Joseph H JH Niles Lisa L Carter Julie H JH Murray Megan M Goetz Christopher G CG Jaglin Jeana J Ahmed Anwar A Russell David S DS Cotto Candace C Goudreau John L JL Russell Doozie D Parashos Sotirios Andreas SA Ede Patricia P Saint-Hilaire Marie H MH Thomas Cathi-Ann CA James Raymond R Stacy Mark A MA Johnson Julia J Gauger Lisa L Antonelle de Marcaida J J Thurlow Sheila S Isaacson Stuart H SH Carvajal Lisbeth L Rao Jayaraman J Cook Maureen M Hope-Porche Charlise C McClurg Lauren L Grasso Daniela L DL Logan Robert R Orme Constance C Ross Tori T Brocht Alicia F D AF Constantinescu Radu R Sharma Saloni S Venuto Charles C Weber Joseph J Eaton Ken K
JAMA neurology 20140201 2
<h4>Importance</h4>Convergent biological, epidemiological, and clinical data identified urate elevation as a candidate strategy for slowing disability progression in Parkinson disease (PD).<h4>Objective</h4>To determine the safety, tolerability, and urate-elevating capability of the urate precursor inosine in early PD and to assess its suitability and potential design features for a disease-modification trial.<h4>Design, setting, and participants</h4>The Safety of Urate Elevation in PD (SURE-PD) ...[more]