Feasibility trial of letrozole in combination with bevacizumab in patients with metastatic breast cancer.

ABSTRACT:

Purpose

Preclinical models suggest that the use of anti-vascular endothelial growth factor (anti-VEGF) therapy with antiestrogens may prevent or delay the development of endocrine therapy resistance. We therefore performed a feasibility study to evaluate the safety of letrozole plus bevacizumab in patients with hormone receptor-positive metastatic breast cancer (MBC).

Methods

Patients with locally advanced breast cancer or MBC were treated with the aromatase inhibitor (AI) letrozole (2.5 mg orally daily) and the anti-VEGF antibody bevacizumab (15 mg/kg intravenously every 3 weeks). The primary end point was safety, defined by grade 4 toxicity using the National Cancer Institute Common Toxicity Criteria, version 3.0. Secondary end points included response rate, clinical benef

SUBMITTER: Traina TA 

PROVIDER: S-EPMC3940895 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature