Ontology highlight
ABSTRACT:
SUBMITTER: Traina TA
PROVIDER: S-EPMC3940895 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Traina Tiffany A TA Rugo Hope S HS Caravelli James F JF Patil Sujata S Yeh Benjamin B Melisko Michele E ME Park John W JW Geneus Stephanie S Paulson Matthew M Grothusen Jill J Seidman Andrew D AD Fornier Monica M Lake Diana D Dang Chau C Robson Mark M Theodoulou Maria M Flombaum Carlos D CD Norton Larry L Hudis Clifford A CA Dickler Maura N MN
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091019 4
<h4>Purpose</h4>Preclinical models suggest that the use of anti-vascular endothelial growth factor (anti-VEGF) therapy with antiestrogens may prevent or delay the development of endocrine therapy resistance. We therefore performed a feasibility study to evaluate the safety of letrozole plus bevacizumab in patients with hormone receptor-positive metastatic breast cancer (MBC).<h4>Methods</h4>Patients with locally advanced breast cancer or MBC were treated with the aromatase inhibitor (AI) letrozo ...[more]