Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy.
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ABSTRACT:
SUBMITTER: Smeets D
PROVIDER: S-EPMC6173768 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy.
Smeets Dominiek D Miller Ian S IS O'Connor Darran P DP Das Sudipto S Moran Bruce B Boeckx Bram B Gaiser Timo T Betge Johannes J Barat Ana A Klinger Rut R van Grieken Nicole C T NCT Cremolini Chiara C Prenen Hans H Mazzone Massimiliano M Depreeuw Jeroen J Bacon Orna O Fender Bozena B Brady Joseph J Hennessy Bryan T BT McNamara Deborah A DA Kay Elaine E Verheul Henk M HM Maarten Neerincx N Gallagher William M WM Murphy Verena V Prehn Jochen H M JHM Koopman Miriam M Punt Cornelis J A CJA Loupakis Fotios F Ebert Matthias P A MPA Ylstra Bauke B Lambrechts Diether D Byrne Annette T AT
Nature communications 20181005 1
Increased copy number alterations (CNAs) indicative of chromosomal instability (CIN) have been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers of bevacizumab (BVZ) response in metastatic colorectal cancer (mCRC). We cluster 409 mCRCs in three subclusters characterized by different degrees of CIN. Tumors belonging to intermediate-to-high instability clusters have improved outcome following chemotherapy plus BVZ versus chemotherapy alone. In contrast, low instabili ...[more]
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