Ontology highlight
ABSTRACT:
SUBMITTER: Mikawa T
PROVIDER: S-EPMC3941061 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Mikawa Takumi T Maruyama Takeshi T Okamoto Koji K Nakagama Hitoshi H Lleonart Matilde E ME Tsusaka Takeshi T Hori Kousuke K Murakami Itsuo I Izumi Taisuke T Takaori-Kondo Akifumi A Yokode Masayuki M Peters Gordon G Beach David D Kondoh Hiroshi H
The Journal of cell biology 20140224 5
Despite the well-documented clinical significance of the Warburg effect, it remains unclear how the aggressive glycolytic rates of tumor cells might contribute to other hallmarks of cancer, such as bypass of senescence. Here, we report that, during oncogene- or DNA damage-induced senescence, Pak1-mediated phosphorylation of phosphoglycerate mutase (PGAM) predisposes the glycolytic enzyme to ubiquitin-mediated degradation. We identify Mdm2 as a direct binding partner and ubiquitin ligase for PGAM ...[more]