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Transcriptional delay stabilizes bistable gene networks.

ABSTRACT: Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable states. Each of the bistable systems that we simulate behaves in this manner.

SUBMITTER: Gupta C

PROVIDER: S-EPMC3941076 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Transcriptional delay stabilizes bistable gene networks.

Gupta Chinmaya C López José Manuel JM Ott William W Josić Krešimir K Bennett Matthew R MR

Physical review letters 20130802 5

Transcriptional delay can significantly impact the dynamics of gene networks. Here we examine how such delay affects bistable systems. We investigate several stochastic models of bistable gene networks and find that increasing delay dramatically increases the mean residence times near stable states. To explain this, we introduce a non-Markovian, analytically tractable reduced model. The model shows that stabilization is the consequence of an increased number of failed transitions between stable ...[more]

PMID: 23952450

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