Ontology highlight
ABSTRACT:
SUBMITTER: Salas E
PROVIDER: S-EPMC3941170 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Journal of diabetes research 20140206
The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. With beta cell self-replication being the primary source for new beta cell generation in adult animals, the network by which beta cell replication could be increased to enhance beta cell mass and function is one of the approaches in diabetes research. In this review, we show a general view of the regulation points at trans ...[more]