Ontology highlight
ABSTRACT:
SUBMITTER: Schratt G
PROVIDER: S-EPMC394242 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Schratt Gerhard G Philippar Ulrike U Hockemeyer Dirk D Schwarz Heinz H Alberti Siegfried S Nordheim Alfred A
The EMBO journal 20040401 8
The transcription factor serum response factor (SRF) controls the expression of genes involved in cellular proliferation and differentiation. Interestingly, SRF also promotes cell survival by regulating the expression of antiapoptotic genes. In in vitro differentiating murine embryonic stem (ES) cells, SRF deficiency leads to increased apoptosis. Loss of SRF correlates with impaired expression of the antiapoptotic Bcl-2 and Bcl-xl genes. SRF binds the Bcl-2 promoter in vivo and activates Bcl-2 t ...[more]