Ontology highlight
ABSTRACT:
SUBMITTER: Nunomura S
PROVIDER: S-EPMC8005361 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Nunomura Satoshi S Nanri Yasuhiro Y Lefebvre Véronique V Izuhara Kenji K
Biochemical and biophysical research communications 20210301
Fibroblast growth factor (FGF10)-mediated signals are essential for embryonic eyelid closure in mammals. Systemic SOX11-deficient mice are born with unclosed eyelids, suggesting a possible role of SOX11 in eyelid closure. However, the underlying mechanisms of this process remain unclear. In this study, we show that epithelial deficiency of SOX11 causes a defect in the extension of the leading edge of the eyelid, leading to failure of embryonic eyelid closure. c-Jun in the eyelid is a transcripti ...[more]