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Epithelial SOX11 regulates eyelid closure during embryonic eye development.


ABSTRACT: Fibroblast growth factor (FGF10)-mediated signals are essential for embryonic eyelid closure in mammals. Systemic SOX11-deficient mice are born with unclosed eyelids, suggesting a possible role of SOX11 in eyelid closure. However, the underlying mechanisms of this process remain unclear. In this study, we show that epithelial deficiency of SOX11 causes a defect in the extension of the leading edge of the eyelid, leading to failure of embryonic eyelid closure. c-Jun in the eyelid is a transcription factor downstream of FGF10 required for the extension of the leading edge of the eyelid, and c-Jun level was decreased in epithelial SOX11-deficient embryos. These results suggest that epithelial SOX11 plays an important role in embryonic eyelid closure.

SUBMITTER: Nunomura S 

PROVIDER: S-EPMC8005361 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Epithelial SOX11 regulates eyelid closure during embryonic eye development.

Nunomura Satoshi S   Nanri Yasuhiro Y   Lefebvre Véronique V   Izuhara Kenji K  

Biochemical and biophysical research communications 20210301


Fibroblast growth factor (FGF10)-mediated signals are essential for embryonic eyelid closure in mammals. Systemic SOX11-deficient mice are born with unclosed eyelids, suggesting a possible role of SOX11 in eyelid closure. However, the underlying mechanisms of this process remain unclear. In this study, we show that epithelial deficiency of SOX11 causes a defect in the extension of the leading edge of the eyelid, leading to failure of embryonic eyelid closure. c-Jun in the eyelid is a transcripti  ...[more]

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