Mechanisms and metabolic implications of regional differences among fat depots.
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ABSTRACT:
SUBMITTER: Tchkonia T
PROVIDER: S-EPMC3942783 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
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Mechanisms and metabolic implications of regional differences among fat depots.
Tchkonia Tamara T Thomou Thomas T Zhu Yi Y Karagiannides Iordanes I Pothoulakis Charalabos C Jensen Michael D MD Kirkland James L JL
Cell metabolism 20130411 5
Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex, genetic background, disease state, certain drugs and hormones, development, and aging. Preadipocyte replication and differentiation, developmental gene expression, susceptibility to apoptosis and cellular senescence, vascularity, inflammatory cell infiltration, and adipokine secretion vary among depots, as do fatty-acid handling and mechanisms of enlargement with positive-energy and loss with negative-ene ...[more]
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