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Molecular characterization and tissue distribution of feline retinol-binding protein 4.

ABSTRACT: Retinol-binding protein 4 (RBP4) is a specific transporter of retinol and was recently identified as an adipokine potentially involved in type 2 diabetes in humans and rodents. However, the function and structure of feline RBP4 have not been reported. In this study, we describe the molecular cloning and expression analysis of feline RBP4. The complete feline RBP4 cDNA encodes a precursor protein comprising an 18 amino acid signal peptide and a 183 amino acid mature protein. Feline RBP4 was mapped to chromosome D2. Mature feline RBP4 is 83-94% homologous to the RBPs of humans, cows and rodents. RT-PCR analysis revealed feline RBP4 expression in liver and adipose tissues.

SUBMITTER: Sasaki N

PROVIDER: S-EPMC3942945 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Molecular characterization and tissue distribution of feline retinol-binding protein 4.

Sasaki Noriyasu N Ishibashi Miwa M Soeta Satoshi S

The Journal of veterinary medical science 20130528 10

Retinol-binding protein 4 (RBP4) is a specific transporter of retinol and was recently identified as an adipokine potentially involved in type 2 diabetes in humans and rodents. However, the function and structure of feline RBP4 have not been reported. In this study, we describe the molecular cloning and expression analysis of feline RBP4. The complete feline RBP4 cDNA encodes a precursor protein comprising an 18 amino acid signal peptide and a 183 amino acid mature protein. Feline RBP4 was mappe ...[more]

PMID: 23719693

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