Ontology highlight
ABSTRACT:
SUBMITTER: Fadel S
PROVIDER: S-EPMC3943289 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20140128
Substituted 3,4-dihydro-1,8-naphthyridin-2(1H)-ones have been synthesized with the inverse electron-demand Diels-Alder reaction from 1,2,4-triazines bearing an acylamino group with a terminal alkyne side chain. Alkynes were first subjected to the Sonogashira cross-coupling reaction with aryl halides, the product of which then underwent an intramolecular inverse electron-demand Diels-Alder reaction to yield 5-aryl-3,4-dihydro-1,8-naphthyridin-2(1H)-ones by an efficient synthetic route. ...[more]