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Intramolecular hydroamination of dithioketene acetals: an easy route to cyclic amino acid derivatives.

ABSTRACT: Catalytic intramolecular hydroamination of dithioketene acetals was developed for the synthesis of cyclic amino acid derivatives. Triggered by the addition of a catalytical amount of n-BuLi, the reaction proceeds to give proline and pipecolic acid derivatives in excellent yields and diastereoselectivity.

SUBMITTER: Xu HC

PROVIDER: S-EPMC3943425 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Intramolecular hydroamination of dithioketene acetals: an easy route to cyclic amino acid derivatives.

Xu Hai-Chao HC Moeller Kevin D KD

Organic letters 20101014 22

Catalytic intramolecular hydroamination of dithioketene acetals was developed for the synthesis of cyclic amino acid derivatives. Triggered by the addition of a catalytical amount of n-BuLi, the reaction proceeds to give proline and pipecolic acid derivatives in excellent yields and diastereoselectivity. ...[more]

PMID: 20945849

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