Ontology highlight
ABSTRACT:
SUBMITTER: Mak PY
PROVIDER: S-EPMC3943601 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Mak P Y PY Mak D H DH Mu H H Shi Y Y Ruvolo P P Ruvolo V V Jacamo R R Burks J K JK Wei W W Huang X X Kornblau S M SM Andreeff M M Carter B Z BZ
Apoptosis : an international journal on programmed cell death 20140401 4
The apoptosis repressor with caspase recruitment domain (ARC) protein is known to suppress both intrinsic and extrinsic apoptosis. We previously reported that ARC expression is a strong, independent adverse prognostic factor in acute myeloid leukemia (AML). Here, we investigated the regulation and role of ARC in AML. ARC expression is upregulated in AML cells co-cultured with bone marrow-derived mesenchymal stromal cells (MSCs) and suppressed by inhibition of MAPK and PI3K signaling. AML patient ...[more]