Ontology highlight
ABSTRACT:
SUBMITTER: Zaiman AL
PROVIDER: S-EPMC4583146 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Zaiman Ari L AL Damico Rachel R Thoms-Chesley Alan A Files D Clark DC Kesari Priya P Johnston Laura L Swaim Mara M Mozammel Shehzin S Myers Alan C AC Halushka Marc M El-Haddad Hazim H Shimoda Larissa A LA Peng Chang-Fu CF Hassoun Paul M PM Champion Hunter C HC Kitsis Richard N RN Crow Michael T MT
Circulation 20111114 23
<h4>Background</h4>Pulmonary hypertension (PH) is a lethal syndrome associated with the pathogenic remodeling of the pulmonary vasculature and the emergence of apoptosis-resistant cells. Apoptosis repressor with caspase recruitment domain (ARC) is an inhibitor of multiple forms of cell death known to be abundantly expressed in striated muscle. We show for the first time that ARC is expressed in arterial smooth muscle cells of the pulmonary vasculature and is markedly upregulated in several exper ...[more]