Ontology highlight
ABSTRACT:
SUBMITTER: Klapoetke NC
PROVIDER: S-EPMC3943671 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Klapoetke Nathan C NC Murata Yasunobu Y Kim Sung Soo SS Pulver Stefan R SR Birdsey-Benson Amanda A Cho Yong Ku YK Morimoto Tania K TK Chuong Amy S AS Carpenter Eric J EJ Tian Zhijian Z Wang Jun J Wang Jun J Xie Yinlong Y Yan Zhixiang Z Zhang Yong Y Chow Brian Y BY Surek Barbara B Melkonian Michael M Jayaraman Vivek V Constantine-Paton Martha M Wong Gane Ka-Shu GK Boyden Edward S ES
Nature methods 20140209 3
Optogenetic tools enable examination of how specific cell types contribute to brain circuit functions. A long-standing question is whether it is possible to independently activate two distinct neural populations in mammalian brain tissue. Such a capability would enable the study of how different synapses or pathways interact to encode information in the brain. Here we describe two channelrhodopsins, Chronos and Chrimson, discovered through sequencing and physiological characterization of opsins ...[more]