Ontology highlight
ABSTRACT:
SUBMITTER: Kim YS
PROVIDER: S-EPMC3943838 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Kim Yu Shin YS Chu Yuxia Y Han Liang L Li Man M Li Zhe Z LaVinka Pamela Colleen PC Sun Shuohao S Tang Zongxiang Z Park Kyoungsook K Caterina Michael J MJ Ren Ke K Dubner Ronald R Wei Feng F Dong Xinzhong X
Neuron 20140123 4
The peripheral terminals of primary nociceptive neurons play an essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and capsaicin. However, the contribution of central terminal TRPV1 in the dorsal horn to chronic pain has not been investigated directly. Combining primary sensory neuron-specific GCaMP3 imaging with a trigeminal neuropathic pain model, we detected robust neuronal hyperactivity in injured and uninjured nerves in the skin, soma in t ...[more]