Ontology highlight
ABSTRACT:
SUBMITTER: Nersesyan Y
PROVIDER: S-EPMC5701661 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nersesyan Yelena Y Demirkhanyan Lusine L Cabezas-Bratesco Deny D Oakes Victoria V Kusuda Ricardo R Dawson Tyler T Sun Xiaohui X Cao Chike C Cohen Alejandro Martin AM Chelluboina Bharath B Veeravalli Krishna Kumar KK Zimmermann Katharina K Domene Carmen C Brauchi Sebastian S Zakharian Eleonora E
Cell reports 20171101 6
Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is an ionotropic oxytocin receptor. Oxytocin elicits TRPV1 activity in native and heterologous expression systems, regardless of the presence of the classical oxytocin receptor. In TRP ...[more]