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Remember the future II: meta-analyses and functional overlap of working memory and delay discounting.

ABSTRACT: Previously we showed that working memory training decreased the discounting of future rewards in stimulant addicts without affecting a go/no-go task. While a relationship between delay discounting and working memory is consistent with other studies, the unique brain regions of plausible causality between these two abilities have yet to be determined. Activation likelihood estimation meta-analyses were performed on foci from studies of delay discounting (DD = 449), working memory (WM = 452), finger tapping (finger tapping = 450), and response inhibition (RI = 450). Activity maps from relatively less (finger tapping) and more (RI) demanding executive tasks were contrasted with maps of DD and WM. Overlap analysis identified unique functional coincidence between DD and WM. The anterior cingulate cortex was engaged by all tasks. Finger tapping largely engaged motor-related brain areas. In addition to motor-related areas, RI engaged frontal brain regions. The right lateral prefrontal cortex was engaged by RI, DD, and WM and was contrasted out of overlap maps. A functional cluster in the posterior portion of the left lateral prefrontal cortex emerged as the largest location of unique overlap between DD and WM. A portion of the left lateral prefrontal cortex is a unique location where delay discounting and working memory processes overlap in the brain. This area, therefore, represents a therapeutic target for improving behaviors that rely on the integration of the recent past with the foreseeable future.

SUBMITTER: Wesley MJ

PROVIDER: S-EPMC3943930 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Remember the future II: meta-analyses and functional overlap of working memory and delay discounting.

Wesley Michael J MJ Bickel Warren K WK

Biological psychiatry 20130913 6

Previously we showed that working memory training decreased the discounting of future rewards in stimulant addicts without affecting a go/no-go task. While a relationship between delay discounting and working memory is consistent with other studies, the unique brain regions of plausible causality between these two abilities have yet to be determined. Activation likelihood estimation meta-analyses were performed on foci from studies of delay discounting (DD = 449), working memory (WM = 452), fing ...[more]

PMID: 24041504

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Project description:IntroductionThe competing neurobehavioral decision systems theory conceptualizes addictive behavior, such as cigarette smoking, as arising from the imbalance between stronger impulsive relative to weaker executive decision processes. Working memory trainings may enhance executive decision processes, yet few studies have evaluated its efficacy on substance misuse, with mixed evidence. The current study is the first to evaluate the efficacy of a working memory training on cigarette smoking. We consider the moderating role of delay discounting (DD), or the preference for smaller, immediately available rewards relative to larger, delayed rewards, which has been associated with smoking onset, progression, and resumption. The investigation focuses on individuals living in high-poverty, low-resource environments due high burden of tobacco-related disease they experience.Aims and methodsThe study utilized a subset of data (N = 177 individuals who smoke) generated from a randomized clinical trial that is evaluating the efficacy of working memory training for improving health-related outcomes. Participants were randomized to complete up to 15 sessions of the active, working memory training or a control training.ResultsFindings showed that among participants who were randomized to the working memory condition, those with higher rates of baseline DD demonstrated decreases in cigarette smoking (p = .05). Conversely, individuals randomized to the control condition, who had higher rates of baseline DD exhibited increases in cigarette smoking (p = .025).ConclusionsResults suggest that DD may be an important indicator of working memory training outcomes and a possible approach for effectively targeting treatments in the future.ImplicationsDD is important indicator of working memory training outcomes on cigarette smoking. The findings suggest the possibility to effectively target treatments considering the impact of DD. Given that rates of DD tend to be higher among individuals from low-resource communities, and that computer-based working memory training programs are relatively low-cost and scalable, these findings suggest this approach may have specific utility for adults at heightened risk for cigarette use.This study was registered with ClinicalTrials.gov (Identifier NCT03501706).

Dataset Information

Remember the future II: meta-analyses and functional overlap of working memory and delay discounting.

Publications

Remember the future II: meta-analyses and functional overlap of working memory and delay discounting.

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