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The Effects of a Working Memory Load on Delay Discounting in Those with Externalizing Psychopathology.

ABSTRACT: This study investigated the influence of executive working memory (EWM) capacity on impulsive decision-making in a sample of young adults (n=623) that varied in degree of externalizing psychopathology (EXT) by examining: (i) the effects of WM load on delay discounting rates, and, (ii) the association between EWM capacity and delay discounting rates. EXT was measured as a latent variable indicated by lifetime problems with alcohol, marijuana, other drugs, childhood conduct, and adult antisocial behavior. Results showed that (i) the WM load increased discounting rates throughout the spectrum of EXT, (ii) EXT was associated with higher discounting rates and lower EMW capacity, and (iii) WM capacity was significantly associated with higher discounting rates when controlling for IQ, but only after a WM load. The results are discussed in terms of the role of EWM capacity in impulsive decision making in EXT.

SUBMITTER: Finn PR

PROVIDER: S-EPMC4399809 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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The Effects of a Working Memory Load on Delay Discounting in Those with Externalizing Psychopathology.

Finn Peter R PR Gunn Rachel L RL Gerst Kyle R KR

Clinical psychological science : a journal of the Association for Psychological Science 20150301 2

This study investigated the influence of executive working memory (EWM) capacity on impulsive decision-making in a sample of young adults (n=623) that varied in degree of externalizing psychopathology (EXT) by examining: (i) the effects of WM load on delay discounting rates, and, (ii) the association between EWM capacity and delay discounting rates. EXT was measured as a latent variable indicated by lifetime problems with alcohol, marijuana, other drugs, childhood conduct, and adult antisocial b ...[more]

PMID: 25893146

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Project description:IntroductionThe competing neurobehavioral decision systems theory conceptualizes addictive behavior, such as cigarette smoking, as arising from the imbalance between stronger impulsive relative to weaker executive decision processes. Working memory trainings may enhance executive decision processes, yet few studies have evaluated its efficacy on substance misuse, with mixed evidence. The current study is the first to evaluate the efficacy of a working memory training on cigarette smoking. We consider the moderating role of delay discounting (DD), or the preference for smaller, immediately available rewards relative to larger, delayed rewards, which has been associated with smoking onset, progression, and resumption. The investigation focuses on individuals living in high-poverty, low-resource environments due high burden of tobacco-related disease they experience.Aims and methodsThe study utilized a subset of data (N = 177 individuals who smoke) generated from a randomized clinical trial that is evaluating the efficacy of working memory training for improving health-related outcomes. Participants were randomized to complete up to 15 sessions of the active, working memory training or a control training.ResultsFindings showed that among participants who were randomized to the working memory condition, those with higher rates of baseline DD demonstrated decreases in cigarette smoking (p = .05). Conversely, individuals randomized to the control condition, who had higher rates of baseline DD exhibited increases in cigarette smoking (p = .025).ConclusionsResults suggest that DD may be an important indicator of working memory training outcomes and a possible approach for effectively targeting treatments in the future.ImplicationsDD is important indicator of working memory training outcomes on cigarette smoking. The findings suggest the possibility to effectively target treatments considering the impact of DD. Given that rates of DD tend to be higher among individuals from low-resource communities, and that computer-based working memory training programs are relatively low-cost and scalable, these findings suggest this approach may have specific utility for adults at heightened risk for cigarette use.This study was registered with ClinicalTrials.gov (Identifier NCT03501706).

Project description:RationaleAlcohol use disorder (AUD) has been associated with greater discounting of delayed monetary rewards, but it is unclear whether this association is primarily related to alcohol consumption or is secondary to the presence of psychiatric comorbidities. It is also unclear if steeper rates of discounting are associated with greater AUD severity.ObjectiveWe sought to determine whether the presence of comorbid psychiatric disorders affected the relationship between AUD and delay discounting. We also examined whether more severe AUD was associated with greater delay discounting.MethodsIn this cross-sectional study, 793 adults completed a delay discounting task. Subjects were divided into four groups based on diagnosis: current AUD with psychiatric comorbidities (N = 226), current AUD without psychiatric comorbidities (N = 203), past AUD (N = 69), and healthy controls (N = 295). In those with AUD, we investigated the relationship between delay discounting and alcohol dependence symptom count and recent drinking history. We also compared individuals seeking treatment to non-treatment seeking individuals. Psychiatric comorbidities examined included mood disorders, anxiety disorders, and substance use disorders.ResultsAfter adjusting for age, sex, income, and education, individuals with current AUD showed significantly higher rates of delay discounting than healthy controls and individuals with a past diagnosis of AUD. The presence of comorbid psychiatric diagnoses was not associated with steeper discounting. Among those with AUD, there was no evidence for a continuous relationship between delay discounting and AUD severity or alcohol consumption. Finally, non-treatment seekers with AUD had steeper delay discounting than treatment seekers.ConclusionsIndividuals with AUD show steeper delay discounting than healthy adults, but the effect is small and there is no added effect from comorbid psychopathology or increased AUD severity. This suggests that steeper delay discounting may have a more limited effect on human alcohol use than previously supposed.

Dataset Information

The Effects of a Working Memory Load on Delay Discounting in Those with Externalizing Psychopathology.

Publications

The Effects of a Working Memory Load on Delay Discounting in Those with Externalizing Psychopathology.

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