Ontology highlight
ABSTRACT:
SUBMITTER: Ferreira AE
PROVIDER: S-EPMC3943997 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Ferreira Ana Elisa AE Sisti Flavia F Sônego Fabiane F Wang Suojuan S Filgueiras Luciano Ribeiro LR Brandt Stephanie S Serezani Ana Paula Moreira AP Du Hong H Cunha Fernando Q FQ Alves-Filho Jose Carlos JC Serezani Carlos Henrique CH
Journal of immunology (Baltimore, Md. : 1950) 20140131 5
Polymicrobial sepsis induces organ failure and is accompanied by overwhelming inflammatory response and impairment of microbial killing. Peroxisome proliferator-activated receptor (PPAR)-γ is a nuclear receptor with pleiotropic effects on lipid metabolism, inflammation, and cell proliferation. The insulin-sensitizing drugs thiazolidinediones (TZDs) are specific PPAR-γ agonists. TZDs exert anti-inflammatory actions in different disease models, including polymicrobial sepsis. The TZD pioglitazone, ...[more]