Ontology highlight
ABSTRACT:
SUBMITTER: Nicolai O
PROVIDER: S-EPMC7205023 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Nicolai Oliver O Pötschke Christian C Schmoeckel Katrin K Darisipudi Murthy N MN van der Linde Julia J Raafat Dina D Bröker Barbara M BM
Frontiers in immunology 20200430
Although antigen-specific priming of antibody responses is impaired during sepsis, there is nevertheless a strong increase in IgM and IgG serum concentrations. Using colon ascendens stent peritonitis (CASP), a mouse model of polymicrobial abdominal sepsis, we observed substantial increases in IgM as well as IgG of all subclasses, starting at day 3 and peaking 2 weeks after sepsis induction. The dominant source of antibody-secreting cells was by far the spleen, with a minor contribution of the me ...[more]