Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC3944329 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Wang Baomei B Zhuang Xiaoying X Deng Zhong-Bin ZB Jiang Hong H Mu Jingyao J Wang Qilong Q Xiang Xiaoyu X Guo Haixun H Zhang Lifeng L Dryden Gerald G Yan Jun J Miller Donald D Zhang Huang-Ge HG
Molecular therapy : the journal of the American Society of Gene Therapy 20130813 3
The gut mucosal immune system is considered to play an important role in counteracting potential adverse effects of food-derived antigens including nanovesicles. Whether nanovesicles naturally released from edible fruit work in a coordinated manner with gut immune cells to maintain the gut in a noninflammatory status is not known. Here, as proof of concept, we demonstrate that grapefruit-derived nanovesicles (GDNs) are selectively taken up by intestinal macrophages and ameliorate dextran sulfate ...[more]