Ontology highlight
ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC4747686 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Gao Jin J Chu Dafeng D Wang Zhenjia Z
Journal of controlled release : official journal of the Controlled Release Society 20160114
Vascular inflammation is the underlying component of most diseases. To target inflamed vasculature, nanoparticles are commonly engineered by conjugating antibody to the nanoparticle surface, but this bottom-up approach could affect nanoparticle targeting and therapeutic efficacy in complex, physiologically related systems. During vascular inflammation endothelium via the NF-κB pathway instantly upregulates intercellular adhesion molecule 1 (ICAM-1) which binds integrin β2 on neutrophil membrane. ...[more]