Ontology highlight
ABSTRACT:
SUBMITTER: Labbe DP
PROVIDER: S-EPMC3944382 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Labbé David P DP Nowak Dawid G DG Deblois Geneviève G Lessard Laurent L Giguère Vincent V Trotman Lloyd C LC Tremblay Michel L ML
Molecular cancer research : MCR 20131230 2
<h4>Unlabelled</h4>The 20q13 chromosomal region has been previously identified as the hereditary prostate cancer genetic-susceptibility locus on chromosome 20 (HPC20). In this study, the 20q13 region was shown to be frequently co-amplified with the androgen receptor (AR) in metastatic prostate cancer. Furthermore, the AR signaling axis, which plays an essential role in the pathogenesis of prostate cancer, was demonstrated to be central to the regulation of the 20q13 common amplified region (CAR) ...[more]