Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene.
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SUBMITTER: Ruiz A
PROVIDER: S-EPMC3944635 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
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Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene.
Ruiz A A Heilmann S S Becker T T Hernández I I Wagner H H Thelen M M Mauleón A A Rosende-Roca M M Bellenguez C C Bis J C JC Harold D D Gerrish A A Sims R R Sotolongo-Grau O O Espinosa A A Alegret M M Arrieta J L JL Lacour A A Leber M M Becker J J Lafuente A A Ruiz S S Vargas L L Rodríguez O O Ortega G G Dominguez M-A MA Mayeux R R Haines J L JL Pericak-Vance M A MA Farrer L A LA Schellenberg G D GD Chouraki V V Launer L J LJ van Duijn C C Seshadri S S Antúnez C C Breteler M M MM Serrano-Ríos M M Jessen F F Tárraga L L Nöthen M M MM Maier W W Boada M M Ramírez A A
Translational psychiatry 20140204
To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ACE data set; 1808 patients and 2564 controls). Our results corroborate association with four SNPs located in the genes INPP5D, MEF2C, ZCWPW1 and FERMT2, respectively. Of these, ZCWPW1 was the only SNP to withstand correction for multiple testing (P=0.000655). Furthermore, we identify TRIP4 ...[more]
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