Dataset Information

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

ABSTRACT:

Introduction

Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.

Methods

We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.

Results

Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10^-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10^-6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10^-6).

Discussion

Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.

SUBMITTER: Jun GR

PROVIDER: S-EPMC5496797 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Publications

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Jun Gyungah R GR Chung Jaeyoon J Mez Jesse J Barber Robert R Beecham Gary W GW Bennett David A DA Buxbaum Joseph D JD Byrd Goldie S GS Carrasquillo Minerva M MM Crane Paul K PK Cruchaga Carlos C De Jager Philip P Ertekin-Taner Nilufer N Evans Denis D Fallin M Danielle MD Foroud Tatiana M TM Friedland Robert P RP Goate Alison M AM Graff-Radford Neill R NR Hendrie Hugh H Hall Kathleen S KS Hamilton-Nelson Kara L KL Inzelberg Rivka R Kamboh M Ilyas MI Kauwe John S K JSK Kukull Walter A WA Kunkle Brian W BW Kuwano Ryozo R Larson Eric B EB Logue Mark W MW Manly Jennifer J JJ Martin Eden R ER Montine Thomas J TJ Mukherjee Shubhabrata S Naj Adam A Reiman Eric M EM Reitz Christiane C Sherva Richard R St George-Hyslop Peter H PH Thornton Timothy T Younkin Steven G SG Vardarajan Badri N BN Wang Li-San LS Wendlund Jens R JR Winslow Ashley R AR Haines Jonathan J Mayeux Richard R Pericak-Vance Margaret A MA Schellenberg Gerard G Lunetta Kathryn L KL Farrer Lindsay A LA

Alzheimer's & dementia : the journal of the Alzheimer's Association 20170207 7

<h4>Introduction</h4>Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.<h4>Methods</h4>We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loc ...[more]

PMID: 28183528

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Dataset Information

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Introduction

Methods

Results

Discussion

Publications

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Similar Datasets

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