Ontology highlight
ABSTRACT:
SUBMITTER: Motta-Mena LB
PROVIDER: S-EPMC3944926 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Motta-Mena Laura B LB Reade Anna A Mallory Michael J MJ Glantz Spencer S Weiner Orion D OD Lynch Kristen W KW Gardner Kevin H KH
Nature chemical biology 20140112 3
Optogenetic gene expression systems can control transcription with spatial and temporal detail unequaled with traditional inducible promoter systems. However, current eukaryotic light-gated transcription systems are limited by toxicity, dynamic range or slow activation and deactivation. Here we present an optogenetic gene expression system that addresses these shortcomings and demonstrate its broad utility. Our approach uses an engineered version of EL222, a bacterial light-oxygen-voltage protei ...[more]