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Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging.

ABSTRACT: OBJECTIVES:To examine differences in a proxy measure of muscle quality across the adult life span and explore potential mechanisms of muscle quality change through identification of cross-sectional correlates of muscle quality. DESIGN:Cross-sectional study. SETTING:Baltimore Longitudinal Study of Aging. PARTICIPANTS:Seven hundred eighty-six individuals with a mean age of 66.3 (range 26-96) (N = 786). A sensitivity analysis was conducted in a subset of participants matched according to sex, muscle mass, and body size. MEASUREMENTS:Muscle quality was operationalized as the ratio of knee-extension strength (isokinetic dynamometry) to thigh muscle cross-sectional area (computed tomography). Differences in muscle strength, muscle area, and muscle quality ratio with age were evaluated, and the association between the muscle quality ratio and measures reflecting domains of cognitive function, motor control, peripheral nerve function, adiposity, glucose homeostasis, and inflammation were assessed through multivariate regression analyses. RESULTS:A linear relationship between age and muscle quality ratio was observed, suggesting a gradual decline in muscle quality over the adult life course. Associations were observed between muscle quality ratio and measures of adiposity, as well as peroneal nerve motor conduction velocity, finger tapping speed, and memory performance (P < .01). The association between muscle quality ratio and nerve conduction velocity was maintained after adjustment for anthropometric measurements (P < .05). CONCLUSION:Muscle quality declines progressively with age over the adult life span and is affected by obesity and neurological factors. Studies are needed to clarify the mechanisms of these associations and their implications for functional outcomes.

SUBMITTER: Moore AZ

PROVIDER: S-EPMC3945403 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging.

Moore Ann Zenobia AZ Caturegli Giorgio G Metter E Jeffrey EJ Makrogiannis Sokratis S Resnick Susan M SM Harris Tamara B TB Ferrucci Luigi L

Journal of the American Geriatrics Society 20140117 2

<h4>Objectives</h4>To examine differences in a proxy measure of muscle quality across the adult life span and explore potential mechanisms of muscle quality change through identification of cross-sectional correlates of muscle quality.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Baltimore Longitudinal Study of Aging.<h4>Participants</h4>Seven hundred eighty-six individuals with a mean age of 66.3 (range 26-96) (N = 786). A sensitivity analysis was conducted in a subset of participants ma ...[more]

PMID: 24438020

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Project description:BACKGROUND:Muscle quality is defined as the force generated by each volumetric unit of muscle tissue. No consensus exists on an optimal measure of muscle quality, impeding comparison across studies and implementation in clinical settings. It is unknown whether muscle quality measures that rely on complex and expensive tests, such as isokinetic dynamometry and computerized tomography correlate with lower extremity performance (LEP) any better than measures derived from simpler and less expensive tests, such as grip strength (Grip) and appendicular lean mass (ALM) assessed by DXA. Additionally, whether muscle quality is more strongly associated with LEP than strength has not been fully tested. OBJECTIVES:This study compares the concurrent validity of alternative measures of muscle quality and characterizes their relationship with LEP. We also whether muscle quality correlates more strongly with LEP than strength alone. DESIGN:Cross-sectional analysis. SETTING:Community. PARTICIPANTS:365 men and 345 women 65 years of age and older in the Baltimore Longitudinal Study of Aging. MEASURES:Thigh cross-sectional area (TCSA), isokinetic and isometric knee extension strength (ID), BMI adjusted ALM (ALMBMI) from DXA, and Grip. Concurrent validity was assessed as the percent variance of different measures of LEP explained by each muscle quality measure. In addition, we compared LEP relationships between each measure of strength and its correspondent value of muscle quality. Confidence intervals for differences in percent variance were calculated by bootstrapping. RESULTS:Grip/ALMBMI explained as much variance as ID/TCSA across all LEP measures in women and most in men. Across all LEP measures, strength explained as much variance of LEP as muscle quality. CONCLUSIONS:Grip/ALMBMI and ID/TCSA measures had similar correlations with LEP. Muscle quality did not outperform strength. Although evaluating muscle quality may be useful to assess age-related mechanisms of change in muscle strength, measures of strength alone may suffice to understand the relationship between muscle and LEP.

Dataset Information

Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging.

Publications

Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging.

Similar Datasets

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