Ontology highlight
ABSTRACT:
SUBMITTER: Bezrookove V
PROVIDER: S-EPMC3945648 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Bezrookove Vladimir V De Semir David D Nosrati Mehdi M Tong Schuyler S Wu Clayton C Thummala Suresh S Dar Altaf A AA Leong Stanley P L SPL Cleaver James E JE Sagebiel Richard W RW Miller James R JR Kashani-Sabet Mohammed M
The Journal of investigative dermatology 20130904 3
Ulceration is an important prognostic factor in melanoma whose biologic basis is poorly understood. Here we assessed the prognostic impact of pleckstrin homology domain-interacting protein (PHIP) copy number and its relationship to ulceration. PHIP copy number was determined using fluorescence in situ hybridization (FISH) in a tissue microarray cohort of 238 melanomas. Elevated PHIP copy number was associated with significantly reduced distant metastasis-free survival (DMFS; P=0.01) and disease- ...[more]