Ontology highlight
ABSTRACT:
SUBMITTER: Webster MR
PROVIDER: S-EPMC3945958 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Webster Marie R MR Kamat Chandrashekhar C Connis Nick N Zhao Ming M Weeraratna Ashani T AT Rudek Michelle A MA Hann Christine L CL Freel Meyers Caren L CL
Molecular cancer therapeutics 20131205 2
Bisphosphonates are used clinically to treat disorders of calcium metabolism and malignant bone disease and are known to inhibit cancer cell growth, adhesion, and invasion. However, clinical use of these agents for the treatment of extraskeletal disease is limited because of low cell permeability. We recently described a bisphosphonamidate prodrug strategy for efficient intracellular release of bisphosphonates, including clodronate (CLO), in non-small cell lung cancer cells. To evaluate anticanc ...[more]