Ontology highlight
ABSTRACT:
SUBMITTER: Webster MR
PROVIDER: S-EPMC3188694 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Webster Marie R MR Zhao Ming M Rudek Michelle A MA Hann Christine L CL Freel Meyers Caren L CL
Journal of medicinal chemistry 20110909 19
Bisphoshonates are used clinically to treat disorders of calcium metabolism, hypercalcemia and osteoporosis, and malignant bone disease. Although these agents are commonly used in cancer patients and have potential direct anticancer effects, their use for the treatment of extraskeletal disease is limited as a result of poor cellular uptake. We have designed and synthesized bisphosphonamidate prodrugs that undergo intracellular activation to release the corresponding bisphosphonate and require on ...[more]