Ontology highlight
ABSTRACT:
SUBMITTER: Tapias V
PROVIDER: S-EPMC3946191 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Tapias Victor V Cannon Jason R JR Greenamyre J Timothy JT
Neurobiology of aging 20131021 5
Numerous factors contribute to the death of substantia nigra (SN) dopamine (DA) neurons in Parkinson's disease (PD). Compelling evidence implicates mitochondrial deficiency, oxidative stress, and inflammation as important pathogenic factors in PD. Chronic exposure of rats to rotenone causes a PD-like syndrome, in part by causing oxidative damage and inflammation in substantia nigra. Pomegranate juice (PJ) has the greatest composite antioxidant potency index among beverages, and it has been demon ...[more]