Unknown

Dataset Information

0

Neuroprotective Effects of Pomegranate Juice against Parkinson's Disease and Presence of Ellagitannins-Derived Metabolite-Urolithin A-In the Brain.


ABSTRACT: Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range of pomegranate's health benefits. While a lot of experimental studies have been devoted to Alzheimer disease and hypoxic-ischemic brain injury, our knowledge of pomegranate's effects against Parkinson's disease (PD) is very limited. It is suggested that its neuroprotective effects are mediated by ETs-derived metabolites-urolithins. In this study, we examined the capability of pomegranate juice for protection against PD in a rat model of parkinsonism induced by rotenone. To evaluate its efficiency, assessment of postural instability, visualization of neurodegeneration, determination of oxidative damage to lipids and ?-synuclein level, as well as markers of antioxidant defense status, inflammation, and apoptosis, were performed in the midbrain. We also check the presence of plausible active pomegranate ETs-derived metabolite, urolithin A, in the plasma and brain. Our results indicated that pomegranate juice treatment provided neuroprotection as evidenced by the postural stability improvement, enhancement of neuronal survival, its protection against oxidative damage and ?-synuclein aggregation, the increase in mitochondrial aldehyde dehydrogenase activity, and maintenance of antiapoptotic Bcl-xL protein at the control level. In addition, we have provided evidence for the distribution of urolithin A to the brain.

SUBMITTER: Kujawska M 

PROVIDER: S-EPMC6981883 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Neuroprotective Effects of Pomegranate Juice against Parkinson's Disease and Presence of Ellagitannins-Derived Metabolite-Urolithin A-In the Brain.

Kujawska Małgorzata M   Jourdes Michael M   Kurpik Monika M   Szulc Michał M   Szaefer Hanna H   Chmielarz Piotr P   Kreiner Grzegorz G   Krajka-Kuźniak Violetta V   Mikołajczak Przemyslaw Łukasz PŁ   Teissedre Pierre-Louis PL   Jodynis-Liebert Jadwiga J  

International journal of molecular sciences 20191227 1


Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range of pomegranate's health benefits. While a lot of experimental studies have been devoted to Alzheimer disease and hypoxic-ischemic brain injury, our knowledge of pomegranate's effects against Parkinson's disease (PD) is very limited. It is suggested that its neuroprotective effects are mediated by ETs-derived metabolites-urolithins. In this study, we examined the capability of pomegranate juice for pr  ...[more]

Similar Datasets

| S-EPMC8074500 | biostudies-literature
| S-EPMC3946191 | biostudies-literature
| S-EPMC10281726 | biostudies-literature
| S-EPMC9144186 | biostudies-literature
| S-EPMC6356990 | biostudies-literature
| S-EPMC9121390 | biostudies-literature
| S-EPMC4041339 | biostudies-literature
| S-EPMC10394011 | biostudies-literature
| S-EPMC6706507 | biostudies-literature
| S-EPMC9139896 | biostudies-literature