Ontology highlight
ABSTRACT:
SUBMITTER: Konitsiotis AD
PROVIDER: S-EPMC3946499 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Konitsiotis Antonios D AD Chang Shu-Chun SC Jovanović Biljana B Ciepla Paulina P Masumoto Naoko N Palmer Christopher P CP Tate Edward W EW Couchman John R JR Magee Anthony I AI
PloS one 20140307 3
Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat). In a pancreatic ductal adenocarcinoma (PDAC) cell line PANC-1 and transfected HEK293a cells Hhat localized to the endoplasmic reticulum. siRNA knockdown showed that Hhat is required for Sonic hedgehog (Shh) palmitoylation, for its assembly into hi ...[more]