Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC4814324 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Li Li L Grausam Katie B KB Wang Jun J Lun Melody P MP Ohli Jasmin J Lidov Hart G W HG Calicchio Monica L ML Zeng Erliang E Salisbury Jeffrey L JL Wechsler-Reya Robert J RJ Lehtinen Maria K MK Schüller Ulrich U Zhao Haotian H
Nature cell biology 20160321 4
Aberrant Notch signalling has been linked to many cancers including choroid plexus (CP) tumours, a group of rare and predominantly paediatric brain neoplasms. We developed animal models of CP tumours, by inducing sustained expression of Notch1, that recapitulate properties of human CP tumours with aberrant NOTCH signalling. Whole-transcriptome and functional analyses showed that tumour cell proliferation is associated with Sonic Hedgehog (Shh) in the tumour microenvironment. Unlike CP epithelial ...[more]