Ontology highlight
ABSTRACT:
SUBMITTER: Albright JC
PROVIDER: S-EPMC3946956 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Albright Jessica C JC Goering Anthony W AW Doroghazi James R JR Metcalf William W WW Kelleher Neil L NL
Journal of industrial microbiology & biotechnology 20131119 2
The use of proteomics for direct detection of expressed pathways producing natural products has yielded many new compounds, even when used in a screening mode without a bacterial genome sequence available. Here we quantify the advantages of having draft DNA-sequence available for strain-specific proteomics using the latest in ultrahigh-resolution mass spectrometry for both proteins and the small molecules they generate. Using the draft sequence of Streptomyces lilacinus NRRL B-1968, we show a >t ...[more]