Ontology highlight
ABSTRACT:
SUBMITTER: Parkinson EI
PROVIDER: S-EPMC5944846 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Parkinson Elizabeth I EI Tryon James H JH Goering Anthony W AW Ju Kou-San KS McClure Ryan A RA Kemball Jeremy D JD Zhukovsky Sara S Labeda David P DP Thomson Regan J RJ Kelleher Neil L NL Metcalf William W WW
ACS chemical biology 20180313 4
Natural products (NPs) are a rich source of medicines, but traditional discovery methods are often unsuccessful due to high rates of rediscovery. Genetic approaches for NP discovery are promising, but progress has been slow due to the difficulty of identifying unique biosynthetic gene clusters (BGCs) and poor gene expression. We previously developed the metabologenomics method, which combines genomic and metabolomic data to discover new NPs and their BGCs. Here, we utilize metabologenomics in co ...[more]